Identification of Long Noncoding RNA Biomarkers for Hepatocellular Carcinoma Using Single-Sample Networks

Table 2

Univariate and multivariate Cox proportional hazards regression analysis.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Training set ()
^aRisk score (high vs. low)	0.526	0.282-0.980	0.043	0.416	0.207-0.836	0.014
Age	1.031	1.006-1.058	0.015	1.029	0.998-1.059	0.061
Sex (male vs. female)	0.851	0.462-1.566	0.605	1.077	0.519-2.236	0.841
Weight	0.999	0.983-1.016	0.939	0.997	0.981-1.014	0.772
Grade (I+II vs. III+IV)	0.138	0.312-0.607	0.009	0.352	0.032-1.524	0.290
Stage (I+III vs. II+IV)	0.379	0.143-1.000	0.050	0.730	0.189-2.830	0.670
Testing set ()
^aRisk score (high vs. low)	0.384	0.197-0.751	0.003	0.459	0.225-0.936	0.032
Age	1.025	0.998-1.053	0.069	1.023	0.994-1.052	0.114
Sex (male vs. female)	0.605	0.325-1.126	0.113	0.711	0.361-1.397	0.322
Weight	0.999	0.983-1.017	0.971	0.999	0.983-1.016	0.979
Grade (I+II vs. III+IV)	1.242	0.166-9.313	0.833	0.510	0.180-1.441	0.996
Stage (I+III vs. II+IV)	0.478	0.204-1.123	0.090	0.675	0.220-2.068	0.204
Entire set ()
^aRisk score (high vs. low)	0.487	0.313-0.756	0.001	0.498	0.313-0.792	0.003
Age	1.028	1.010-1.047	0.002	1.023	1.004-1.043	0.017
Sex (male vs. female)	0.715	0.463-1.105	0.131	0.811	0.506-1.299	0.384
Weight	0.999	0.988-1.011	0.930	0.999	0.988-1.011	0.966
Grade (I+II vs. III+IV)	0.436	0.134-1.418	0.168	0.582	0.116-2.910	0.510
Stage (I+III vs. II+IV)	0.427	0.226-0.804	0.008	0.570	0.256-1.269	0.169

Notes. ^aDerived from the 3-lncRNA-based risk score model.