Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and Dissolution Rate of Deferasirox

Table 2

Composition of pellet formulations amount of (all ingredients are reported as %w/w based on the weight of core material).

Formulation	DFX	Polymer		Lactose (filler)	Talc (anti-tacking agent)	Aerosil (glidant)
		PEG 4000	PVP K25
F1	2	2	—	30	1	1
F2	2	6	—	26	1	1
F3	2	10	—	22	1	1
F4	2	—	2	30	1	1
F5	2	—	6	26	1	1
F6	2	—	10	22	1	1
F7	2	—	—	32	1	1

DFX: deferasirox; Na-CMC: sodium carboxymethyl cellulose; Aerosil: silicon dioxide.