Research Article
BASP1 Suppresses Cell Growth and Metastasis through Inhibiting Wnt/β-Catenin Pathway in Gastric Cancer
Figure 5
BASP1 overexpression inhibited the activation of the Wnt/β-catenin pathway in AGS and HGC-27 cells. (a) The qRT-PCR results showed that BASP1 overexpression significantly decreased the mRNA expressions of WT1, Wnt, and β-catenin in AGS cells. (b) Western blot analysis also revealed that BASP1 overexpression markedly reduced the protein expressions of WT1, Wnt, and β-catenin in AGS cells. (c) The qRT-PCR results revealed that BASP1 overexpression significantly decreased the mRNA expressions of WT1, Wnt, and β-catenin in HGC-27 cells. (d) Western blot analysis also demonstrated that BASP1 overexpression significantly decreased the protein expressions of WT1, Wnt, and β-catenin in HGC-27 cells. vs. the Control and pcDNA3.1-NC groups.
(a) |
(b) |
(c) |
(d) |