Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Table 7

Antiproliferative activity of ursolic acid and thujone on U-937 and HL-60 cell lines.

Concentration (µmol/mL)	% Cell viability
	Ursolic acid		Thujone
	U-937 CL	HL-60 CL	U-937 CL	HL-60 CL
03.13	73.15 ± 2.01^h	69.64 ± 0.68^h	90.17 ± 1.08^h	96.33 ± 0.78^h
06.25	65.18 ± 1.86^g	66.92 ± 1.31^h	85.80 ± 0.64^g	88.88 ± 0.91^g
12.50	59.63 ± 0.67^f	56.29 ± 0.75^g	78.38 ± 1.64^f	83.22 ± 1.10^f
25.00	54.69 ± 0.64^e	50.44 ± 0.79^f	71.38 ± 1.03^e	77.48 ± 1.66^e
50.00	44.66 ± 1.35^d	45.18 ± 0.75^e	69.67 ± 0.68^e	71.15 ± 1.23^d
100.0	32.74 ± 2.58^c	39.01 ± 1.17^d	64.59 ± 1.20^d	56.22 ± 0.70^c
250.0	27.67 ± 1.28^b	33.37 ± 1.17^c	53.85 ± 1.80^c	52.66 ± 1.52^b
500.0	23.08 ± 1.65^a	29.15 ± 0.55^b	42.51 ± 0.73^b	49.67 ± 0.69^b
1000	19.67 ± 0.98^a	23.70 ± 1.27^a	37.29 ± 1.43^a	44.66 ± 1.26^a

Control, nil mortality. The values are mean of triplicates with standard deviation (mean ± S.D; n = 3). Different superscript letters (a–i) in column within treatments indicates significant differences (at ) when subject to Tukey’s multiple comparison test, CL, cell line.