The Utility of Diffusion and Perfusion Magnetic Resonance Imaging in Target Delineation of High-Grade Gliomas

Table 2

Univariate and multivariate analyses. Clinical parameters affecting the overall survival of all patients in univariate and multivariate analyses.

Characteristic	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Age
>50	1 (referent)
≤50	0.98 (0.63-1.50)	0.90
Gender
Male	1 (referent)
Female	1.24 (0.79-1.94)	0.34
Adjuvant-therapy
Yes	1 (referent)
No	0.94 (0.60-1.48)	0.80
Combined with epilepsy
Yes	1 (referent)		1 (referent)
No	0.67 (0.37-1.20)	0.18	0.57 (0.31-1.05)	0.07
Mental functions
Normal	1.21 (0.67-2.19)
Dysfunction	1 (referent)	0.53
Dose
≥60 Gy	0.67 (0.33-1.34)		0.74 (0.36-1.50)
<60 Gy	1 (referent)	0.26	1 (referent)	0.40
WHO grade
III	1 (referent)
IV	0.83 (0.53-1.29)	0.40
MRI
Multimodality MRI+CE-MRI	1 (referent)		1 (referent)
CE-MRI alone	1.81 (1.16-2.82)	0.01	1.99 (1.26-3.16)	0.003