Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population
Table 1
Associations between ten SNPs in the miR-30 family members and breast cancer risk.
SNP
Chr
Position (hg38)
Location
Allelesa
Casesb ()
Controlsb ()
Call rate (%)
MAFc (case/control)
HWEd
OR (95% CI)e
valuee
rs763354
6
71405918
2.4 kb upstream of pre-miR-30a
G/A
155/478/407
188/499/365
97.89
0.38/0.42
0.447
0.86 (0.75-0.98)
0.022
rs852963
6
71412803
9.3 kb upstream of pre-miR-30a
G/A
69/341/652
45/353/672
99.77
0.23/0.21
0.926
1.09 (0.93-1.26)
0.293
rs852964
6
71413926
10.4 kb upstream of pre-miR-30a
G/A
150/482/431
127/489/457
99.95
0.37/0.35
0.893
1.12 (0.98-1.28)
0.085
rs928508
1
40757742
458 bp upstream of pre-miR-30c-1
A/G
239/515/308
242/512/319
99.91
0.47/0.46
0.197
1.05 (0.92-1.19)
0.462
rs12743517
1
40759682
2.4 kb upstream of pre-miR-30c-1
C/A
201/516/346
189/519/365
99.95
0.43/0.42
0.851
1.03 (0.91-1.17)
0.647
rs3767950
1
40767541
10.3 kb upstream of pre-miR-30c-1
C/A
160/472/430
158/481/432
99.81
0.37/0.37
0.214
1.02 (0.9-1.16)
0.758
rs12208417
6
71385948
9.0 kb upstream of pre-miR-30c-2
C/A
241/527/295
233/549/290
99.91
0.47/0.47
0.392
0.99 (0.87-1.12)
0.832
rs16881192
6
71386063
9.1 kb upstream of pre-miR-30c-2
A/C
83/420/553
80/400/586
99.30
0.28/0.26
0.305
1.1 (0.95-1.27)
0.197
rs17709260
8
134810212
5.3 kb upstream of pre-miR-30d
A/G
12/144/908
3/134/936
100
0.08/0.07
0.616
1.23 (0.96-1.57)
0.107
rs7846345
8
134814337
9.4 kb upstream of pre-miR-30d
G/C
180/526/358
185/505/383
100
0.42/0.41
0.411
1.01 (0.89-1.15)
0.854
aMajor/minor allele. bMajor homozygote/heterozygote/rare homozygote between cases and controls. cMinor allele frequency (MAF). d values for the Hardy-Weinberg equilibrium (HWE) test. eLogistic regression analysis with adjustment for age, age at menarche, and menopausal status in the additive model. Chr: chromosome; OR: odds ratio; CI: confidence interval.
