Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population
Table 3
Stratification analysis of association between rs763354 in the regulatory region of miR-30a and risk of breast cancer.
Characteristics
Case
Control
OR (95% CI)a
b
Age
0.226
≤51
232/276/97
198/253/100
0.92 (0.78-1.09)
0.344
>51
175/202/58
167/246/88
0.79 (0.65-0.95)
0.015
Age at menarche
0.869
≤16
298/356/116
222/300/115
0.87 (0.74-1.01)
0.063
>16
103/112/37
143/198/72
0.85 (0.67-1.06)
0.151
Age at first live birth
0.652
≤24
134/175/53
176/247/91
0.89 (0.73-1.09)
0.258
>24
246/274/93
176/242/90
0.84 (0.70-1.00)
0.052
Age at natural menopause
0.435
≤49
72/75/23
81/112/32
0.88 (0.65-1.19)
0.411
>49
102/126/37
84/136/54
0.75 (0.58-0.97)
0.030
Menopausal status
0.938
Premenopausal
198/231/76
181/229/89
0.87 (0.72-1.04)
0.117
Postmenopausal
204/243/76
180/260/93
0.86 (0.72-1.02)
0.091
ER status
0.107
Positive
179/224/78
0.89 (0.76-1.04)
0.152
Negative
163/158/45
0.73 (0.61-0.87)
0.0005
PR status
0.159
Positive
192/225/81
0.88 (0.75-1.03)
0.126
Negative
149/156/44
0.74 (0.62-0.89)
0.001
aPer allele odds ratio (OR) and 95% confidence interval (CI) adjusted for age, age at menarche, and menopausal status where appropriate. b for heterogeneity test.
