Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation

Figure 4

Functional enrichment analysis from ReactomeFIViz and ClueGO. (a) The column bar graph from ReactomeFIViz. It shows the top 10 significantly related pathways, including nuclear receptor transcription pathway, glutathione conjugation, interleukin-4 and 13 signaling, regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs), and phase II conjugation. (b) The pie chart from ClueGO. It shows the enriched signaling pathway categories based on the kappa coefficient, including positive regulation of lipid metabolic process, regulation of smooth muscle cell proliferation, fatty acid transport, positive regulation of reactive oxygen species metabolic process, regulation of phosphatidylinositol 3-kinase signaling, and alpha-amino acid metabolic process. (c) The functional enrichment network from ClueGO. The node represents the signaling pathway, and the size of each node represents the enrichment significance of each signaling pathway. The larger the node is, the more significant the pathway is. The line represents the correlation between functions, and the thickness of each line represents the kappa coefficient between functions. The thicker the line is, the greater the kappa coefficient is.

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