Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation

Figure 6

The PPARα, LXRα, and HNF4α structure models docked with corresponding ligands. The protein structures are visualized with the ribbon model. The residues and the ligands are visualized with the stick model. (a) PPARα was docked with hyperin at the binding sites of TYR 334 and MET 220 residues; (b) LXRα was also docked with hyperin at the binding sites of GLN 222, GLU 267, and ARG 305 residues; (c) HNF4α was docked with linolenic acid ethyl ester at the binding sites of ARG 226 residues.

(a)

(b)

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