Identification of 5-Gene Signature Improves Lung Adenocarcinoma Prognostic Stratification Based on Differential Expression Invasion Genes of Molecular Subtypes

Table 2

Univariate and multivariate Cox survival analysis.

Feature	Univariable analysis				Multivariable analysis
	HR	95% CI of HR			HR	95% CI of HR
		Lower	Upper			Lower	Upper
Age
≤65				0.192				0.068
>65	1.217	0.906	1.635		1.406	0.976	2.025
Gender
Female				0.747				0.813
Male	1.049	0.784	1.405		0.957	0.667	1.375
T stage
T1-T2				<1-5				0.008
T3-T4	2.298	1.568	3.366		1.934	1.19	3.143
N stage
N0				<1-5				0.002
N1-N3	2.58	1.918	3.47		1.986	1.292	3.054
M stage
M0				0.006				0.226
M1	2.133	1.245	3.654		1.515	0.773	2.967
Smoking
1				0.536				0.541
2-4	0.878	0.581	1.326		0.852	0.51	1.423
Stage
I+II				<1-5				0.678
III+IV	2.584	1.893	3.527		1.118	0.66	1.892
RiskType
Low				<1-5				<1-5
High	2.497	1.834	3.4		2.165	1.461	3.209