The Prognostic Significance of miR-21 Expression among Surgically Resected Hepatocellular Carcinoma Patients: Evidence from a Meta-Analysis and Retrospective Cohort Study

Table 1

Correlation between miR-21 expression and clinicopathological features.

Patient characteristics	Number	miR-21 expression		value
		Low ()	High ()
Gender
Male	87	48	39	0.162
Female	79	35	44
Age (years)
<55	46	25	21	0.488
≥55	120	58	62
Tumor size (cm)
≤5	132	74	58	0.002
>5	34	9	25
Tumor number
Single	133	72	61	0.032
Multiple	33	11	22
Serum AFP (μg/l)
<400	47	21	26	0.389
≥400	119	62	57
Liver cirrhosis
Absence	38	17	21	0.46
Presence	128	66	62
Tumor differentiation
Well+moderate	101	63	38	<0.001
Poor	65	20	45
TNM stage
I-II	96	60	36	<0.001
III-IV	70	23	47
Vascular infiltration
Absence	121	66	55	0.055
Presence	45	17	28

miR-21: microRNA-21; AFP: α-fetoprotein.