The Prognostic Significance of miR-21 Expression among Surgically Resected Hepatocellular Carcinoma Patients: Evidence from a Meta-Analysis and Retrospective Cohort Study

Table 2

Univariate and multivariate Cox regression analysis for OS.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years)	1.160 (0.556-2.418)	0.693
Gender	0.781 (0.412-1.481)	0.45
Tumor size	3.784 (1.339-10.700)	0.012	3.902 (1.273-11.956)	0.017
Tumor number	2.377 (1.217-4.640)	0.011
Tumor differentiation	2.766 (1.427-5.361)	0.003
TNM stage	3.232 (1.627-6.420)	0.001
Vascular infiltration	2.467 (1.273-4.784)	0.007	2.56 (1.162, 5.6399)	0.019
Cirrhosis	1.971 (1.005-3.866)	0.048
AFP	1.731 (0.855-3.505)	0.127
miR-21 expression	3.368 (1.622-6.993)	0.001	2.361 (1.016-5.490)	0.046

OS: overall survival; miR-21: microRNA-21; AFP: α-fetoprotein; HR: hazard ratio; CI: confidence interval.