The Prognostic Significance of miR-21 Expression among Surgically Resected Hepatocellular Carcinoma Patients: Evidence from a Meta-Analysis and Retrospective Cohort Study

Table 3

Univariate and multivariate Cox regression analysis for DFS/RFS.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years)	1.201 (0.582-2.478)	0.62
Gender	0.760 (0.402-1.437)	0.398
Tumor size	1.773 (0.879-3.575)	0.11
Tumor number	2.377 (1.082-8.667)	0.035	2.243 (1.035-4.862)	0.041
Tumor differentiation	2.994 (1.540-5.823)	0.001
TNM stage	3.381 (1.697-6.733)	0.001
Vascular infiltration	2.053 (1.078-3.910)	0.029
Cirrhosis	2.009 (0.374-10.791)	0.416
AFP	1.845 (1.022-3.329)	0.042
miR-21 expression	3.179 (1.569-6.442)	0.001	2.02 (1.042-3.92)	0.037

DFS/RFS: disease-free survival/recurrence-free survival; miR-21: microRNA-21; AFP: α-fetoprotein; HR: hazard ratio; CI: confidence interval.