Research Article
Identification of Core Prognosis-Related Candidate Genes in Chinese Gastric Cancer Population Based on Integrated Bioinformatics
Table 2
The top 15 GO terms of BP, CC, and MF of upregulated and downregulated genes.
| Category | (A) The top 15 enriched GO terms of upregulated genes | Term | Count | value |
| BP | Extracellular matrix organization | 20 | 2.12-20 | BP | Cell adhesion | 22 | 9.65-16 | BP | Collagen fibril organization | 10 | 1.05-13 | BP | Collagen catabolic process | 11 | 2.79-13 | BP | Skeletal system development | 11 | 6.47-10 | CC | Extracellular matrix | 24 | 6.15-23 | CC | Proteinaceous extracellular matrix | 22 | 5.02-21 | CC | Extracellular region | 40 | 7.52-21 | CC | Extracellular space | 37 | 1.93-20 | CC | Collagen trimer | 13 | 5.06-15 | MF | Extracellular matrix structural constituent | 12 | 3.51-15 | MF | Integrity binding | 9 | 1.32-08 | MF | Calcium ion binding | 16 | 2.27-07 | MF | Extracellular matrix binding | 5 | 4.00-06 | MF | Heparin binding | 8 | 4.82-06 |
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| Category | (B) The top 15 enriched GO terms of downregulated genes | Term | Count | value |
| BP | Digestion | 14 | 2.25-15 | BP | Xenobiotic metabolic process | 9 | 1.95-07 | BP | Steroid metabolic process | 6 | 2.27-05 | BP | Cellular aldehyde metabolic process | 4 | 7.82-05 | BP | Oxidation-reduction process | 15 | 2.75-04 | CC | Extracellular space | 36 | 6.18-10 | CC | Extracellular exosome | 48 | 5.83-07 | CC | Organelle membrane | 7 | 7.91-05 | CC | Apical plasma membrane | 9 | 0.002747 | CC | Basolateral plasma membrane | 6 | 0.016259 | MF | Oxidoreductase activity | 8 | 9.13-04 | MF | Aryl sulfotransferase activity | 3 | 0.003693 | MF | Aldo-keto reductase (NADP) activity | 3 | 0.005787 | MF | Retinol dehydrogenase activity | 3 | 0.008306 | MF | Inward rectifier potassium channel activity | 3 | 0.010212 |
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BP: biological process; CC: cellular component; MF: molecular function.
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