Network Pharmacology-Based and Clinically Relevant Prediction of the Potential Targets of Chinese Herbs in Ovarian Cancer Patients

Figure 7

Effect of aqueous extract of 12 herbs on cell proliferation, cell migration, and predicted targets. (a) The statistical views of cell proliferation (left) and cell inhibition rate (right). The 12 herbs had obvious inhibitory effects on cell proliferation after 72 hours at doses of 100 μg/mL, 125 μg/mL, and 150 μg/mL in vitro. (b) The result of Transwell. The aqueous extract also significantly suppressed cell migration at 16 hours (). (c) Western blot assay analyzed NF-κB, p-NF-κB, TP53, p-TP53, VDR, FAS, BCL-2, and CDK1A, after the treatment of aqueous extract of 12 herbs.

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