Network Pharmacology-Based and Clinically Relevant Prediction of the Potential Targets of Chinese Herbs in Ovarian Cancer Patients

Table 2

Univariate and Multivariate analyses of variables influencing survival of 202 patients with OvCa.

	Univariate analysis		Multivariate analysis
Characteristics	(%)	value	β	Exp (β)	95% CI	value
Age (years)		0.028	0.332	1.394	0.984-1.975	0.062
<45	37 (18.3)
45-59	129 (63.9)
≥60	36 (17.8)
Tumor location		<0.001	0.384	1.468	1.083-1.990	0.013
Left	31 (15.3)
Right	63 (31.2)
Bilateral	108 (53.5)
Pathological pattern		0.023	0.044	1.045	0.837-1.303	0.669
Endometrioid adenocarcinoma	46 (22.8)
Serous adenocarcinoma	137 (67.8)
Other types	19 (9.4)
FIGO stage		<0.001	0.841	2.320	1.688-3.188	<0.001
Stage I	10 (5.0)
Stage II	37 (18.3)
Stage III	126 (62.4)
Stage IV	29 (14.4)
CA-125 (kU/L)		0.009	0.426	1.531	0.888-2.641	0.126
<35	5 (2.5)
35-280	36 (17.8)
>280	161 (79.7)
Chemotherapy method		0.034	0.856	2.353	1.427-3.882	0.001
Intravenous injection	171 (84.7)
Intravenous injection+intraperitoneal perfusion	31 (15.3)
Radiotherapy		0.032	1.186	3.273	1.018-10.522	0.047
Yes	14 (6.9)
No	188 (93.1)
Biotherapy		0.421	—	—	—	—
Yes	52 (25.7)
No	150 (74.3)
Targeted therapy		0.236	—	—	—	—
Yes	10 (5.0)
No	192 (95.0)
CHM		0.004	-0.853	0.426	0.279-0.650	<0.001
Yes	87 (43.1)
No	115 (56.9)