Network Pharmacology-Based and Clinically Relevant Prediction of the Potential Targets of Chinese Herbs in Ovarian Cancer Patients

Table 3

The major ingredients and major targets of the 12 herbs involved in OvCa treatment.

Chinese name	Latin name	Major ingredients	Number of targets	Major targets	Average dosage(g)	Correlation coefficient	value
附子	Radix Aconiti Lateralis Preparata	Higenamine (RALP-3); P-Aminophenol (RALP-9)	14	EPO; FAS; FASLG	6	0.313	0.002
杜仲	Cortex Eucommiae	Civetone (CE-17); Epiquinidine (CE-23); N-Triacontanol (CH-46)	90	BCL2; TP53; NFKB1; VDR	10	0.353	0.004
蛤蚧	Gecko	Glutathion (G-3); Guanine (G-4)	60	BCL2; TP53; VDR	5	0.336	0.006
益母草	Herba Leonuri	Guanine (HL-6); Lauric acid (HL-8)	78	BCL2; TP53; VDR	30	0.328	0.008
生姜	Rhizoma Zingiberis	Coprine (RZ-49); Shyobunone (RZ-121); Zingiberone (RZ-131)	143	BCL2; TP53; NFKB1; VDR	10	0.327	0.008
马鞭草	Herba Verbenae	Adenosine (HV-2)	31	WNT4; NFKB1; BAX; VDR	30	0.315	0.011
王不留行	Semen Vaccariae	Hydroginkgolinic acid (SV-1); Melanin (SV-3)	39	BCL2; TP53; VDR	30	0.313	0.011
桑寄生	Herba Taxilli	Beta-amyrin (HT-2); Oleanolic acid (HT-5)	14	NFKB1; BAX; VDR	15	0.307	0.013
商陆	Radix Phytolaccae	Esculentic acid (RP-3); Jaligonic acid (RP-15)	9	ANXA1; VDR	9	0.301	0.015
三七	Radix Notoginseng	Coprine (RN-15); Heneicosanic acid (RN-44); Hexadecanoic acid (RN-48); Nonadecanoic acid (RN-55); Pentadecanoic acid (RN-69)	118	BCL2; TP53; NFKB1; VDR	2	0.293	0.018
桂枝	Ramulus Cinnamomi	Anethole (RC-4); Styrene (RC-20)	59	NFKB1; VDR; BCL2L11	10	0.292	0.018
牡丹皮	Cortex Moutan	Gallicacid (CM-5); Suffruticosol A (CM-17)	15	WNT4; VDR; ESR2	9	0.272	0.028