Identification and Analysis of Estrogen Receptor α Promoting Tamoxifen Resistance-Related lncRNAs

Figure 5

Identification of ERα directly promoting lncRNAs. (a) Pie graph of the percentage of protein-coding genes and lncRNAs of ERα binding genes (-3 kb_3 kb region) in MCF-7/WT-E2 (WT-E2) and MCF-7/TamR-E2 (TAMR-E2) cells and misregulated genes in MCF-7/TamR cells. (b) Venn plot of overlap lncRNAs of unique ERα binding lncRNAs (-3 kb_3 kb region) in MCF-7/WT-E2 (WT-E2) cells and downregulated lncRNAs in MCF-7/TamR cells and box plot of the relationship between relative expression level (log2) of overlap lncRNAs and the ERα status (positive or negative). (c) Venn plot of overlap lncRNAs of unique ERα binding lncRNAs (-3 kb_3 kb region) in MCF-7/TamR-E2 (TAMR-E2) cells and upregulated lncRNAs in MCF-7/TamR cells and box plot of the relationship between relative expression level (log2) of overlap lncRNAs and the ERα status.

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