Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling

Figure 2

Deficiency of AMPKα abolished crocin-induced protective effects on glucose metabolic activity in type 2 diabetic mice. Type 2 diabetes was induced in wild type and AMPKα mice using high-fat diet incorporated with STZ injection. The type 2 diabetic mice were treated with crocin or vehicle. (a) Fasting blood glucose level (). (b) Serum insulin level (). (c) Area curve under the curve of IPGTT (). (d) Area curve under the curve of IPITT (). , , .

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