Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling

Figure 4

Deficiency of AMPKα abolished crocin-induced effects on CDK5/PPARγ in type 2 diabetic mice. Type 2 diabetes was induced in wild type and AMPKα mice using high-fat diet incorporated with STZ injection. The type 2 diabetic mice were treated with crocin or vehicle. (a) CDK5 expression and phosphorylation of PPARγ in adipose tissue were determined using western blot (). (b–h) mRNA expression of CDK5/PPARγ targets was determined using RT-qPCR (). , , , .

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