Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients
Table 2
Comparison of characteristics between 28-day survivors and 28-day nonsurvivors.
Variable
Survivors ()
Nonsurvivors ()
Gender (male), % (n)
71.82 (79)
72.22 (13)
0.99
Age (year)
47.60 (45.18-50.02)
48.75 (41.83-55.67)
0.55
APACHE II score
20.00 (18.54-20.34)
22.00 (20.43-24.40)
0.01
SOFA score
7.50 (7.15-7.93)
8.50 (7.64-9.92)
0.04
Severe sepsis or septic shock, % ()
20.00 (22)
61.11 (11)
<0.001
Underlying disease, % ()
Hypertension
20.91 (23)
22.22 (4)
0.99
Diabetes
8.18 (9)
16.67 (3)
0.37
Infection site, % ()
Respiratory
66.36 (73)
61.11 (11)
0.79
Abdomen
19.09 (21)
16.67 (3)
0.99
Urinary tract
4.55 (5)
5.56 (1)
0.99
Blood
43.64 (48)
55.56 (10)
0.45
Others
3.64 (4)
5.56 (1)
0.54
Laboratory parameters
WBC (×109)
13.64 (9.78-15.28)
15.49 (10.46-18.77)
0.11
LC (×109)
0.79 (0.74-0.84)
0.61 (0.49-0.72)
0.003
CRP (pg/ml)
67.05 (60.39-73.71)
84.80 (62.52-107.1)
0.13
PCT (pg/ml)
1.75 (1.53-1.96)
2.36 (1.85-2.86)
0.02
IL-6 (pg/ml)
332.8 (262.9-402.6)
623.0 (460.9-785.0)
0.002
IL-1β (pg/ml)
18.83 (16.67-20.99)
23.63 (15.45-31.80)
0.25
IL-18 (pg/ml)
420.4 (354.3-486.6)
693.8 (568.4-819.3)
<0.001
Values are presented as median (95% confidence interval (CI)) or percentage (%). APACHE: acute physiology and chronic health evaluation; SOFA: sequential organ failure assessment; LC: lymphocyte count; WBC: white blood cells; CRP: C-reactive protein; PCT: procalcitonin.
