Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients

Table 4

Cox proportional hazard model of PBMC pyroptosis and 28-day mortality.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Sex (age)	0.686	0.240-1.957	0.481
Age (year)	0.978	0.944-1.014	0.224
APACHE II score	1.366	1.124-1.660	0.002	1.148	0.903-1.458	0.259
Lymphocyte count	3.731	0.178-78.132	0.396
PBMC pyroptosis	1.345	1.157-1.564	≤0.001	1.234	1.014-1.502	0.036
IL-18	1.002	1.000-1.004	0.088
IL-6	1.000	0.999-1.002	0.675
PCT	2.673	1.248-5.723	0.011	1.828	0.753-4.438	0.182

APACHE: acute physiology and chronic health evaluation; PBMCs: peripheral blood mononuclear cells; IL: interleukin; PCT: procalcitonin.