Research Article

Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease

Figure 4

The receiver operating characteristic (ROC) curve analyses for plasma exosomal SOCS2-AS1 as a diagnostic biomarker of CAD. (a) The area under ROC curve (AUC) was 0.704 (95% CI = 0.607–0.801, ) for diagnosis of CAD patients. The sensitivity and specificity at the optimal cut-off were 71.4% and 63.4%. (b) The AUC was 0.709 (95% CI = 0.607–0.811, ) for diagnosing severe subgroup of CAD patients (≥75% luminal stenosis of any coronary vessel). The sensitivity and specificity at the optimal cut-off were 67.2% and 68.3%. (c) The AUC was 0.698 (95% CI = 0.588–0.807, ) for diagnosis of mild coronary artery stenosis (mCAS) patients (50% ≥ luminal stenosis of any coronary vessel >0). The sensitivity and specificity at the optimal cut-off were 72.9% and 63.4%.
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