Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer

Figure 4

The uptake and intracellular distribution of Wy5a-SPIO/FDA-NPs in PC-3 cells by CLSM. The FDA dyes (green) were formulated into PLGA-PEG-aptamer triblock nanoparticles by nanoprecipitation instead of Dtxl. Nuclei and lysosomes were stained with Hoechst 33342 (blue) and Lyso-Tracker (Red), respectively.