Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer

<div>(a) Prussian blue staining images (×200) of PC-3 cells incubated with Wy5a-SPIO/Dtxl-NPs at Fe concentrations of 0, 60, 80, and 100 <i>μ</i>g/mL. (b) T2-weighted imaging of PC-3 cells incubated with Wy5a-SPIO/Dtxl-NPs at a series of Fe concentrations. (c) <i>In vitro</i> T2-weighted images of PC-3 cells incubated with Wy5a-SPIO/Dtxl-NPs, SPIO/Dtxl-NPs, and mutWy5a-SPIO/Dtxl-NPs and DU145 cells incubated with Wy5a-SPIO/Dtxl-NPs.</div>

BioMed Research International

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Figure 5

Figure 5: Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer 

Figure 5 | Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer 