Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest

Figure 5

Isoliquiritigenin (ILQ) inhibited tumor growth of xenograft in vivo. The KYSE-140 xenograft was established in nude mice and then treated with 10 mg/kg ILQ every two days. The antitumor ability was investigated. (a) The photograph of tumors; (b) the growth curve of xenograft; (c) the weight of tumors; (d) the body weight of tumor-bearing mice during in vivo experiment. (e) ILQ decreased phosphor-EGFR and Ki67 in tumor tissue. The phosphorylation of EGFR and Ki67 in ILQ-treated tumor tissue was analyzed by immunohistochemistry staining as described. Left, the representative photography; right, the expression of indicated markers was quantified.

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