Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest

Figure 6

The proposed antitumor mechanisms of ILQ in ESCC cells. With the suppression of EGFR activation, the activities of ERK1/2 and AKT were inhibited, leading to the decrease of AP-1 transcriptional activity and the reduction of cyclin D1 expression, which contributed to the G0/G1 cell cycle arrest.