Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation

Table 1

Association between DNMT3 mutation and clinicopathological parameters.

Clinicopathological variables	Cases (170)	DNMT3A		value
		Mutation (43)	Wild type (127)
Sex
Male	89	22	67	0.862
Female	81	21	60
Age (years)
<60	89	43	46	<0.001
≥60	81	0	81
FAB type
M0	15	3	12	0.326
M1	44	12	32
M2	38	12	26
M3	16	7	9
M4	32	4	28
M5	18	4	14
M6	2	0	2
M7	3	0	3
Unknown	2	1	1
Blast in BM
<50%	34	6	28	0.28
≥50%	136	37	99
Blast in PB
<50%	99	17	82	0.006
≥50%	68	25	43
Unknown	3	1	2
WBC (×10^9/L)
<10	68	15	53	0.475
≥10	102	28	74
FLT3 mutation
Yes	49	18	31	0.034
No	121	25	96

Blast in BM: blast percentage in bone marrow; blast in PB: blast percentage in peripheral blood; WBC: white blood cell.