Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Stroke among Patients with Hypertension

Table 2

Genotype frequency distribution in cases and controls.

Variable	Strokes, (%)	Control, (%)			OR	95% CI	OR	95% CI
rs2989924
AA	41 (19.5)	117 (19.0)	8.260	0.016	1.00
AG	86 (41.0)	317 (51.4)			0.774	0.505-1.188	0.645	0.409-1.018
GG	83 (39.5)	183 (29.7)			1.294	0.833-2.010	1.292	0.817-2.043
AA	41 (19.5)	117 (19.0)	0.032	0.858	1.00
AG+GG	169 (80.5)	500 (81.0)			0.965	0.649-1.433	0.885	0.585-1.340
AA+AG	127 (60.5)	434 (70.3)	6.987	0.008	1.00
GG	83 (39.5)	183 (29.7)			1.550	1.119-2.148	1.741	1.232-2.461
rs3758269
CC	164 (77.7)	456 (72.2)	2.958	0.228	1.00
CT	44 (20.9)	159 (25.2)			0.769	0.527-1.124	0.687	0.456-1.035
TT	3 (1.4)	17 (2.7)			0.491	0.142-1.696	0.500	0.143-1.754
CC	164 (77.7)	456 (72.2)	2.525	0.112	1.00
CT+TT	47 (22.3)	176 (27.8)			0.743	0.514-1.073	0.669	0.450-0.994
CC+CT	208 (98.6)	615 (97.3)	1.098	0.295	1.00
TT	3 (1.4)	17 (2.7)			0.522	0.151-1.798	0.545	0.156-1.904
rs62542743
CC	192 (91.0)	584 (92.3)	0.361	0.835	1.00
CA	18 (8.5)	46 (7.3)			1.190	0.674-2.102	1.054	0.573-1.939
AA	1 (0.5)	3 (0.5)			1.014	0.105-9.804	0.935	0.093-9.371
CC	192 (91.0)	584 (92.3)	0.341	0.559	1.00
CA+AA	19 (9.0)	49 (7.7)			1.179	0.678-2.053	1.047	0.579-1.892
CC+CA	210 (99.5)	630 (99.5)	0.000	1.000	1.00
AA	1 (0.5)	3 (0.5)			1.000	0.103-9.665	0.931	0.093-9.325
rs57139208
CC	163 (77.3)	491 (77.6)	0.980	0.613	1.00
CT	46 (21.8)	130 (20.5)			1.066	0.729-1.559	1.068	0.717-1.591
TT	2 (0.9)	12 (1.9)			0.502	0.111-2.267	0.284	0.036-2.254
CC	163 (77.3)	491 (77.6)	0.009	0.924	1.00
CT+TT	48 (22.7)	142 (22.4)			1.018	0.702-1.477	1.005	0.679-1.488
CC+CT	209 (99.1)	621 (98.1)	0.872	0.351	1.00
TT	2 (0.9)	12 (1.9)			0.495	0.110-2.231	0.280	0.035-2.218
rs16939881
CC	184 (87.2)	551 (87.0)	0.442	0.802	1.00
CG	26 (12.3)	76 (12.0)			1.024	0.637-1.648	1.038	0.632-1.704
GG	1 (0.5)	6 (0.9)			0.499	0.060-4.173	0.554	0.065-4.686
CC	184 (87.2)	551 (87.0)	0.004	0.953	1.00
CG+GG	27 (12.8)	82 (13.0)			0.986	0.619-1.571	1.002	0.617-1.628
CC+CG	210 (99.5)	627 (99.1)	0.432	0.511	1.00
GG	1 (0.5)	6 (0.9)			0.498	0.060-4.157	0.551	0.065-4.661

OR: odds ratio; CI: confidence interval. Adjusted for age, gender, systolic blood pressure, fasting glucose, total cholesterol, triglycerides, and low-density lipoprotein cholesterol.