Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats

<div>Overexpression of POSTN in OVX-BMSCs increased the expression of POSTN, Wnt3a, <i>β</i>-catenin, and osteogenic differentiation. (a) Higher expression of POSTN, Wnt3a, and <i>β</i>-catenin was observed via western blot in the Lev-POSTN than in the Lev-GFP group; there was no significant difference relative to the sham group. (b) RT-PCR showing partly restored mRNA levels of <i>Postn</i>, <i>RUNX2</i>, and <i>ALP</i> of OVX-BMSCs following POSTN overexpression<i>.</i> (c) Overexpression of POSTN partially restored ALP activity of OVX-BMSCs. 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BioMed Research International

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Figure 4

Figure 4: Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats 