Research Article
miR-520h Stimulates Drug Resistance to Paclitaxel by Targeting the OTUD3-PTEN Axis in Breast Cancer
Table 1
Relationship between miR-520h, OTUD3, and PTEN expression and the clinicopathologic characteristics in breast cancer.
| Clinicopathologic characteristics | miR-520h | | OTUD3 | | PTEN | | High | Low | High | Low | High | Low |
| Age | | | 0.079 | | | 0.308 | | | 0.745 | ≤50 | 49 | 22 | | 22 | 49 | | 26 | 45 | | >50 | 47 | 38 | | 33 | 52 | | 29 | 56 | | Tumor size | | | 0.041 | | | 0.007 | | | 0.001 | ≤2 cm | 48 | 40 | | 39 | 49 | | 41 | 47 | | >2 cm | 48 | 20 | | 16 | 52 | | 14 | 54 | | Histological grade | | | 0.027 | | | 0.009 | | | 0.300 | I | 32 | 28 | | 30 | 30 | | 25 | 35 | | II | 42 | 13 | | 15 | 39 | | 15 | 39 | | III | 23 | 19 | | 10 | 32 | | 15 | 27 | | Lymph nodes | | | 0.030 | | | 0.025 | | | 0.594 | Negative | 50 | 42 | | 39 | 16 | | 34 | 58 | | Positive | 46 | 18 | | 53 | 48 | | 21 | 43 | | ER status | | | 0.521 | | | 0.503 | | | 0.545 | Negative | 20 | 10 | | 9 | 21 | | 12 | 18 | | Positive | 76 | 50 | | 46 | 80 | | 43 | 83 | | PR status | | | 0.233 | | | 0.513 | | | 0.409 | Negative | 25 | 21 | | 18 | 28 | | 20 | 26 | | Positive | 71 | 39 | | 37 | 73 | | 33 | 75 | | HER2 status | | | 0.074 | | | 0.371 | | | 0.066 | Negative | 78 | 55 | | 45 | 88 | | 43 | 90 | | Positive | 18 | 5 | | 10 | 13 | | 12 | 11 | |
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