Lack of PPARβ/δ-Inactivated SGK-1 Is Implicated in Liver Carcinogenesis

Figure 1

Role of PPARβ/δ in the upregulation of HCC. Mouse livers were excised after eight months of DEN treatment. (a) The photograph shows reduced tumor growth in the PPARβ/δ^(+/+) mice compared to the PPARβ/δ^(-/-) mice. (b) Hematoxylin-eosin-stained liver tissue sections of mice. (c) Representative histological results from HCC tissues showing HCC in hematoxylin-eosin-stained liver tissue sections of mice (magnification, 100x and 400x). Arrows indicate microscopic HCC. (d) Incidence of HCC development in PPARβ/δ^(+/+) and PPARβ/δ^(-/-) mice, which were kept under observation for eight months after the administration of DEN.

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