Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches

Table 10

Urinalysis of rats treated with sericin extract for 90 days.

Dose (mg/kg)	Number of abnormal color/clarity	SG	pH	Number of positive
				WBC	KET	NIT	URO	BIL	PRO	GLU	BLD	Cr	Ca	MA
Male
1000	0			0	0	0	0	0	3	0	2	0	2	2
500	0			2	0	0	0	0	3	0	2	1	2	3
250	0			1	0	0	0	0	2	0	2	0	1	2
Control	0			2	0	0	0	0	3	0	2	1	2	2
Female
1000	0			0	0	0	0	0	1	0	1	0	2	1
500	0			1	0	0	0	0	2	0	1	0	1	1
250	0			0	0	0	0	0	0	0	2	0	1	1
Control	0			1	0	0	0	0	2	0	2	0	2	1

Note: The values of SG and pH represent the of 10 rats. SG: specific gravity; WBC: white blood cell; KET: ketone body; NIT: nitrite; URO: urobilinogen; BIL: bilirubin; PRO: protein; GLU: glucose; BLD: occult blood; Cr: creatinine; Ca: calcium; MA: microalbumin. The values of the treatment groups did not differ statistically from the control according to one-way ANOVA at .