Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches

Table 11

Histopathology examination of rats treated with sericin extract for 90 days.

Organs	Histopathological changes	Male		Female
		1000 mg/kg	Control	1000 mg/kg	Control
Liver	Inflammatory cell infiltration in portal duct areas	2	1	1	2
	Mild spotty necrosis of hepatocytes	1	1	1	1
	Mild fatty degeneration of hepatocytes	1	2	2	2
Kidneys	Cell infiltration in renal cortex	1	2	2	1

Note: The values represent the number of rats with histopathological changes in 10 rats of each group.