Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches

Table 3

Results of the mammalian erythrocyte micronucleus test for water-extract sericin.

Groups	Number of mice examined	Number of PCE examined	Number of micronucleated PCE observed	Micronucleated PCE (‰)	Number of RBC examined	Number of PCE observed	PCE/RBC
Male
6660	5		13			232
3330	5		16			240
1665	5		15			237
Negative	5		15			223
Positive	5		219			156
Female
6660	5		14			226
3330	5		14			241
1665	5		15			224
Negative	5		14			229
Positive	5		213			164

PCE: polychromatic erythrocyte; RBC: red blood cell. For micronucleated PCE and PCE/RBC, the data represent the of 5 animals. Significant difference compared to the control at .