Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches

Table 4

Results of mouse spermatogonia chromosomal aberration test for sericin extract.

Group (mg/kg)	Number of cells examined	Chromosomal number abnormality		Alteration of chromosomal structure						Number of cells with chromosomal aberration	Rate of cells with chromosomal aberration (%)
		Aneuploid	Polyploid	Gaps	Breakage	Fragment	Microchromosome	Circular	Others
6660 (24 h)		0	36	28	10	26	0	1	0	101
6660 (48 h)		0	36	22	10	24	1	0	0	93
3330		0	33	23	10	23	0	1	0	90
1665		0	35	32	12	12	1	1	0	93
Negative control		0	37	20	11	24	1	1	0	92
Positive control		0	37	47	99	164	2	7	0	356

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