Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches

Table 9

Serum biochemical examination of rats treated with sericin extract for 90 days.

(a)

Dose (mg/kg)	AST (U/L)	ALT (U/L)	BUN (mmol/L)	CR (μmol/L)	TC (mmol/L)	TG (mmol/L)	TP (g/L)
Male
1000
500
250
Control
Female
1000
500
250
Control

(b)

Dose (mg/kg)	ALB (g/L)	GLU (mmol/L)	GGT (U/L)	ALP (U/L)	Cl (mmol/L)	K (mmol/L)	Na (mmol/L)
Male
1000
500
250
Control
Female
1000
500
250
Control

Note: The values represent the of 10 rats. AST: aspartate transaminase; ALT: alanine transaminase; BUN: blood urea nitrogen; CR: creatinine; TC: total cholesterol; TG: triglyceride; TP: total protein; ALB: albumin; GLU: glucose; GGT: glutamyltransferase; ALP: alkaline phosphatase; Cl: chlorine; K: potassium; Na: Natrium. The values of the treatment groups did not differ statistically from the control according to one-way ANOVA at .