Research Article
Identification of Potential Biomarkers for Thyroid Cancer Using Bioinformatics Strategy: A Study Based on GEO Datasets
Table 3
GO analysis of integrated DEGs.
(a) Upregulated genes top 9 enriched GO terms |
| | Category | Term | Count | PValue | Adj.P-value |
| | Upregulated | | | | | | GOTERM_CC_DIRECT | GO:0005576~extracellular region | 33 | 6.02E-07 | 6.53E-05 | | GOTERM_CC_DIRECT | GO:0005615~extracellular space | 30 | 4.51E-07 | 9.78E-05 | | GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 43 | 1.38E-05 | 9.94E-04 | | GOTERM_CC_DIRECT | GO:0016324~apical plasma membrane | 11 | 9.61E-05 | 0.005198329 | | GOTERM_CC_DIRECT | GO:0033116~endoplasmic reticulum-Golgi intermediate compartment membrane | 6 | 1.41E-04 | 0.006102825 | | GOTERM_CC_DIRECT | GO:0005578~proteinaceous extracellular matrix | 9 | 0.001212652 | 0.032377398 | | GOTERM_CC_DIRECT | GO:0030054~cell junction | 12 | 9.49E-04 | 0.033762537 | | GOTERM_CC_DIRECT | GO:0009986~cell surface | 13 | 0.001109523 | 0.033828883 | | GOTERM_MF_DIRECT | GO:0008201~heparin binding | 8 | 2.89E-04 | 0.041460423 |
|
|
(b) Downregulated genes top 7 enriched GO terms |
| | Category | Term | Count | PValue | Adj.P-value |
| | Downregulated | | | | | | GOTERM_BP_DIRECT | GO:0006590~thyroid hormone generation | 5 | 2.64E-06 | 0.002657461 | | GOTERM_BP_DIRECT | GO:0030509~BMP signaling pathway | 7 | 5.37E-05 | 0.026654296 | | GOTERM_CC_DIRECT | GO:0005578~proteinaceous extracellular matrix | 15 | 7.80E-08 | 1.45E-05 | | GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 50 | 3.91E-07 | 2.42E-05 | | GOTERM_CC_DIRECT | GO:0005615~extracellular space | 32 | 3.46E-07 | 3.22E-05 | | GOTERM_CC_DIRECT | GO:0005576~extracellular region | 30 | 9.41E-05 | 0.004366683 | | GOTERM_CC_DIRECT | GO:0043235~receptor complex | 7 | 7.88E-04 | 0.028910743 |
|
|
(a) Top 9 enriched GO terms of upregulated DEGs. (b) Top 7 enriched GO terms of downregulated DEGs.
|
