Identification of Potential Biomarkers for Thyroid Cancer Using Bioinformatics Strategy: A Study Based on GEO Datasets

Table 4

Pathway analysis of integrated DEGs.

(a) Pathways of upregulated DEGs

ID	Pathway	Count	P-value	Adj.P-Val
Upregulated
KEGG:05222	Small cell lung cancer	9.00	8.62532E-08	6.46899E-06
R-HSA:8952289	FAM20C phosphorylates FAM20C substrates	9.00	3.15636E-07	2.3357E-05
R-HSA:8957275	Post-translational protein phosphorylation	9.00	3.15636E-07	2.3357E-05
R-HSA:1474244	Extracellular matrix organization	13.00	1.53637E-06	0.000110619
WP:2814	Mammary gland development pathway - puberty (stage 2 of 4)	4.00	3.29235E-06	0.000233757
KEGG:04512	ECM-receptor interaction	7.00	5.8434E-06	0.000409038
WP:366	TGF-beta signaling pathway	8.00	1.67948E-05	0.001158841
R-HSA:1474228	Degradation of the extracellular matrix	8.00	2.43709E-05	0.001657223
KEGG:04115	p53 signaling pathway	6.00	3.20579E-05	0.002147877
R-HSA:3000170	Syndecan interactions	4.00	7.37454E-05	0.004867193

(b) Pathways of downregulated DEGs

ID	Pathway	Count	P-value	Adj.P-Val
Downregulated
R-HSA:209968	Thyroxine biosynthesis	4.00	1.02232E-06	2.2491E-05
R-HSA:209776	Amine-derived hormones	4.00	1.41298E-05	0.000296725
R-HSA:5661231	Metallothioneins bind metals	3.00	9.55155E-05	0.00191031
R-HSA:5660526	Response to metal ions	3.00	0.000206804	0.00392928
KEGG:00350	Tyrosine metabolism	4.00	0.000241586	0.004348555
R-HSA:3560782	Diseases associated with glycosaminoglycan metabolism	4.00	0.000401916	0.006832565
R-HSA:2161282	Elastic fibres bind associated proteins	3.00	0.000452188	0.007235015
R-HSA:1630316	Glycosaminoglycan metabolism	6.00	0.000673119	0.01009678
KEGG:04978	Mineral absorption	4.00	0.000928833	0.013003667
WP:2895	Differentiation of white and brown adipocyte	3.00	0.001220241	0.01586313

(a) Pathways of upregulated DEGs. (b) Pathways of downregulated DEGs.