Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer

<div>A2M-AS1 is upregulated in breast cancer tissues in the GEO dataset and associated with worse prognosis. (a) Volcano plot of 399 dysregulated lncRNAs and 11070 dysregulated mRNAs identified by hierarchical clustering in GSE45827. (b) Volcano plot of 383 dysregulated lncRNAs and 11164 dysregulated mRNAs identified by hierarchical clustering in GSE65216. A2M-AS1 expression in human breast cancer tumour tissues and normal tissues was detected by RNA microarray using GSE45827 (c) and GSE65216 (d). High expression of A2M-AS1 is associated with poor recurrence-free (e) and metastasis-free survival (f) rates. (g) A2M-AS1 is more highly expressed in ER-negative tissues than in ER-positive tissues. (h) A2M-AS1 is more highly expressed in basal-like and Her2+ tissues than in luminal A and luminal B tissues. 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BioMed Research International

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Figure 1

Figure 1: Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer 