The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity

Table 2

Univariate and multivariate analyses of prognostic parameters for survival in 225 NPC patients.

Prognostic parameter	Univariate analysis		Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Expression of ICOSL (low vs. high)	2.865	1.284–3.621	0.001	2.475	0.987–3.701	0.001
Age (y)	1.512	0.814–1.722	0.049	—	—	—
Sex (male vs. female)	1.894	0.921–2.422	0.032	—	—	—
Tumor differentiation	1.545	0.713–1.934	0.096	1.857	0.756–1.875	0.077
T classification	2.870	1.274–3.897	0.014	2.947	0.941–2.356	0.022
Lymphatic metastasis (present vs. absent)	4.231	2.287–5.214	0.003	4.985	2.241–5.877	0.001
Distant metastasis (present vs. absent)	5.121	3.038–7.145	0.001	5.636	2.514–7.031	0.001

BMI: body mass index; HR: hazard ratio; CI: confidence interval.