Effects of 12-Week Exercise Program on Enzyme Activity of Serum Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Female Patients with Postmenopausal Osteoporosis: A Randomized Control Study

Table 2

Changes in enzyme activity of serum MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio in EG and CG.

	Baseline	12 weeks	value^1
MMP-9 (ng/mL)
Exercise group	785.19 ± 511.76	456.57 ± 284.90	0.009
Control group	731.19 ± 788.3	595.06 ± 481.19	0.583
value^2	0.075	0.538
TIMP-1 (ng/mL)
Exercise group	27.59 ± 30.06	350.32 ± 313.93	<0.001
Control group	26.74 ± 28.75	32.64 ± 25.21	0.210
value^2	0.777	<0.001
Ratio MMP-9/TIMP-1
Exercise	46.97 ± 38.86	1.59 ± 0.82	<0.001
Control group	34.59 ± 40.69	25.37 ± 32.56	0.028
value^2	0.018	<0.001

¹Wilcoxon Signed Ranks test. ²Mann–Whitney test.