Effects of 12-Week Exercise Program on Enzyme Activity of Serum Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Female Patients with Postmenopausal Osteoporosis: A Randomized Control Study

Table 3

The difference between enzyme activity of serum MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio in the exercise and control groups after 12 weeks adjusted for baseline values of age, BMI, vitamin D, and total PTH and Ca.

	Adjusted^1 β	95% CI	value	Adjusted^2 β	95% CI	p value
MMP-9 (ng/mL)	143.54	−45.13–332.21	0.133	147.08	−43.95–338.12	0.129
TIMP-1 (ng/mL)	−322.08	−436.74–207.41	<0.001	−318.32	−433.44–203.21	<0.001
Ratio MMP-9/TIMP-1	24.02	13.32–34.73	<0.001	23.73	13.00–34.46	<0.001

Adjusted¹ β: adjusted for age, baseline BMI, and baseline Vitamin D. Adjusted² β: adjusted for age, BMI, Vitamin D, total PTH, and Ca. 95% CI: 95% confidence interval.