Anticolorectal Cancer Effects of AUCAN: Effects to Suppress Proliferation, Metastasis, and Invasion of Tumor Cells

Figure 7

The effect of AUCAN administration on tumor growth in nude mice. The (a) morphology, (b) weight, (c) PET-CT assay, and (e) SUV of tumor in nude mice after administration of DMSO (control) and AUCAN with 10 mg/kg and 20 mg/kg. . (d) The relative volume of tumor in nude mice in above groups at 3, 6, 9, 12, 15, and 18 d, respectively. (f, g) The radiance of the tumor in nude mice after the addition of DMSO (control) and AUCAN with 10 mg/kg and 20 mg/kg. (h) The proliferation rate of tumor in nude mice administered with 10 mg/kg and 20 mg/kg AUCAN at 3, 6, 9, 12, 15, and 18 d, respectively. (i) Ponderal growth of nude mice with tumor at 2, 4, 5, 8, 10, 12, 14, 16, 18, 20, and 22 d, respectively. (j) The HGB concentration of tumor and the concentration of (k) AST, ALT, (l) WBC, and PLT in the control and AUCAN with 10 mg/kg and 20 mg/kg groups. All data are shown as the , /group. and . Con: control; C₁₇H₁₇NO₆: AUCAN; d: day; HGB: hemoglobin; ns: no significance; WBC: white blood cell; PLT: platelet; AST: aspartate aminotransferase; ALT: alanine transaminase.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)