Anticolorectal Cancer Effects of AUCAN: Effects to Suppress Proliferation, Metastasis, and Invasion of Tumor Cells

Figure 8

The effects of AUCAN treatment on cell proliferation and cell apoptosis in nude mice in vivo. (a) The HE staining of tumor tissue in nude mice in vivo among the control, 10 mg/kg AUCAN, and 20 mg/kg AUCAN groups. . (b) The immunohistochemistry Ki67 in nude mice in vivo among these four groups. . (c) The TUNEL staining of tumor tissues in nude mice in vivo among the indicated groups. Apoptotic cells are stained by red, and the nucleus is stained by blue. . (d) Ki67+ cell number and (e) TUNEL-positive cell number among the control, 10 mg/kg AUCAN, and 20 mg/kg AUCAN groups. All data are shown as the , /group. the AUCAN 10 mg/kg group vs. the control group, the AUCAN 20 mg/kg vs. the control group, and ^&P <0.05 the AUCAN 20 mg/kg group vs. the AUCAN 10 mg/kg group. Con: control; C₁₇H₁₇NO₆: AUCAN; HE: hematoxylin and eosin staining; DAPI: 4’,6-diamidino-2-phenylindole; TUNEL: terminal deoxynucleotidyl transferase dUTP-biotin nick end labeling assay.

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