Microarray Data Mining and Preliminary Bioinformatics Analysis of Hepatitis D Virus-Associated Hepatocellular Carcinoma

Figure 4

PPI networks and the top-3 significant modules (module 1-3). (a) PPI networks constructed with the DEGs closely related to HDV-associated HCC. The red border indicates upregulation, the blue border indicates downregulation, the pink core represents module 1, the green core represents module 2, the dark blue core represents module 3, and the size of the circle represents the relative expression level of the genes; (b) module 1, the DEGs in module 1 are all downregulated; (c) module 2, the DEGs in module 2 are all downregulated; (d) module 3, the DEGs in module 3 are upregulated except for PPP2R5C and LONRF1. PPI: protein-to-protein interaction; DEGs: differentially expressed genes.

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