Synergistic Antiproliferative Effects of All-Trans Retinoic Acid and Paclitaxel on Autosomal Dominant Polycystic Kidney Disease Epithelial Cells

Figure 2

Combination treatment with PAC and ATRA induces cell cycle arrest at the G2/M phase. WT 9-7 cells were treated with DMSO or the combination of 1 nM PAC and 10 nM ATRA for 48 h. To examine cell cycle arrest, the cells were fixed with 4% formaldehyde for 15 min and then incubated with PI in a buffer containing RNase and analyzed by flow cytometry. .

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