Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma

Table 2

Univariate and multivariate Cox analysis of the determinants of overall survival (OS) of patients with gastric signet ring cell carcinoma (GSRC).

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age at diagnose (years)
18-44	1
45-64	1.118 (0.937-1.334)	0.215
Race
Black	1		1
Other	0.672 (0.517-0.873)	0.003	0.658 (0.501-0.864)	0.003
White	0.948 (0.765-1.174)	0.624	0.870 (0.694-1.090)	0.226
Sex
Female	1
Male	0.974 (0.840-1.129)	0.722
Marital status
Married	1		1
Unmarried	1.210 (1.036-1.412)	0.016	1.108 (0.943-1.301)	0.214
Primary site
Proximal third (cardia and fundus)	1		1
Mid third (body and lesser curvature)	0.741 (0.588-0.934)	0.011	0.815 (0.642-1.035)	0.094
Distal third (antrum and pylorus)	0.882 (0.713-1.092)	0.249	0.831 (0.664-1.040)	0.106
Greater curvature	0.932 (0.661-1.313)	0.687	0.887 (0.625-1.258)	0.500
Overlapping lesions	1.314 (1.012-1.705)	0.040	0.808 (0.613-1.065)	0.130
NOS	0.985 (0.712-1.362)	0.927	0.870 (0.623-1.215)	0.413
Grade
Moderately differentiated (II)	1
Poorly differentiated (III)	1.230 (0.695-2.178)	0.477
Undifferentiated (IV)	1.362 (0.701-2.645)	0.362
T stage
T1	1		1
T2	2.624 (1.598-4.310)	<0.001	2.562 (1.534-4.278)	<0.001
T3	5.877 (3.951-8.740)	<0.001	4.668 (3.028-7.195)	<0.001
T4	11.257 (7.604-16.670)	<0.001	7.353 (4.740-11.406)	<0.001
N stage
N0	1		1
N1	2.189 (1.678-2.854)	<0.001	1.327 (1.001-1.759)	0.049
N2	2.689 (2.091-3.458)	<0.001	1.528 (1.166-2.002)	0.002
N3	4.496 (3.580-5.647)	<0.001	1.724 (1.312-2.265)	<0.001
M stage
M0	1		1
M1	3.547 (2.958-4.254)	<0.001	2.113 (1.746-2.557)	<0.001
Tumor size (cm)
≤5	1		1
>5	2.338 (2.010-2.720)	<0.001	1.276 (1.082-1.504)	0.004
PLNE
<15	1		1
≥15	2.800 (2.335-3.357)	<0.001	1.418 (1.135-1.771)	0.002
Radiation
No/unknown	1
Yes	0.909 (0.784-1.055)	0.211
Chemotherapy
No/unknown	1		1
Yes	1.399 (1.176-1.666)	<0.001	0.669 (0.555-0.807)	<0.001
Year of diagnose	0.964 (0.942-0.987)	0.002	1.000 (0.976-1.025)	0.987

HR: hazard ratio; CI: confidence interval; PLNE: number of positive lymph nodes.