Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
Table 3
Univariate and multivariate Cox analysis of the determinants of cancer-specific survival (CSS) of patients with gastric signet ring cell carcinoma (GSRC).
Variables
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
Age at diagnose (years)
18-44
1
45-64
1.127 (0.935-1.358)
0.209
Race
Black
1
1
Other
0.644 (0.487-0.853)
0.002
0.613 (0.462-0.813)
<0.001
White
0.967 (0.771-1.212)
0.769
0.859 (0.681-1.082)
0.197
Sex
Female
1
Male
0.969 (0.829-1.132)
0.688
Marital status
Married
1
Unmarried
1.170 (0.993-1.378)
0.060
Primary site
Proximal third (cardia and fundus)
1
1
Mid third (body and lesser curvature)
0.732 (0.573-0.934)
0.012
0.811 (0.630-1.045)
0.105
Distal third (antrum and pylorus)
0.880 (0.703-1.101)
0.263
0.835 (0.659-1.057)
0.134
Greater curvature
0.886 (0.613-1.279)
0.518
0.840 (0.578-1.222)
0.362
Overlapping lesions
1.347 (1.027-1.769)
0.032
0.818 (0.613-1.092)
0.174
NOS
0.961 (0.681-1.356)
0.822
0.853 (0.598-1.217)
0.381
Grade
Moderately differentiated (II)
1
Poorly differentiated (III)
1.207 (0.665-2.193)
0.536
Undifferentiated (IV)
1.398 (0.701-2.791)
0.342
T stage
T1
1
1
T2
2.957 (1.636-5.347)
<0.001
2.760 (1.502-5.072)
0.001
T3
7.929 (4.907-12.812)
<0.001
5.951 (3.557-9.955)
<0.001
T4
15.347 (9.540-24.688)
<0.001
9.408 (5.590-15.836)
<0.001
N stage
N0
1
1
N1
2.350 (1.760-3.138)
<0.001
1.345 (0.992-1.823)
0.057
N2
2.926 (2.225-3.848)
<0.001
1.555 (1.163-2.080)
0.003
N3
5.091 (3.972-6.525)
<0.001
1.780 (1.332-2.379)
<0.001
M stage
M0
1
1
M1
3.764 (3.119-4.542)
<0.001
2.193 (1.801-2.670)
<0.001
Tumor size (cm)
≤5
1
1
>5
2.448 (2.086-2.873)
<0.001
1.278 (1.076-1.519)
0.005
PLNE
<15
1
1
≥15
2.910 (2.410-3.515)
<0.001
1.428 (1.135-1.797)
0.002
Radiation
No/unknown
1
Yes
0.898 (0.768-1.051)
0.179
Chemotherapy
No/unknown
1
1
Yes
1.492 (1.237-1.800)
<0.001
0.698 (0.572-0.851)
<0.001
Year of diagnose
0.958 (0.935-0.982)
<0.001
0.996 (0.971-1.022)
0.742
HR: hazard ratio; CI: confidence interval; PLNE: number of positive lymph nodes.
