Drug Repurposing for Alzheimer’s Disease Based on Protein-Protein Interaction Network

Table 1

List of the selected clusters along with their genes.

Number of clusters	Number of nodes	Nodes
1	31	PPARG, CAMK2D, RXRA, SP1, ESR2, GRIN2B, FAS, POU2F1, CDKN2A, NOS3, AR, CCNT1, ABCA1, RUNX1, VDR, NME8, UBE2I, TP63, TP73, PPARA, NR1H2, UBD, PNMT, TBX3, ESR1, CLOCK, SNX3, PIN1, TP53, BCR, CAV1
3	22	PSENEN, APH1A, TARDBP, NCSTN, PSEN1, APP, UBQLN1, APBB1, APBB3, COL25A1, BACE2, BACE1, TRAK2, KLC1, CTSD, MAPK8IP1, APH1B, TGFB1, CD14, APBB2, PSEN2, TLR4
6	19	GSTP1, DAPK1, EIF2AK2, SLC6A3, SNCA, UBE2D1, LRP6, NLRP3, RAB7A, LRRK2, YWHAQ, GSK3B, TRAF2, TNF, SLC6A4, RCAN1, EIF4EBP1, UNC5C, SERPINA1
7	13	NEDD9, NGF, SORCS3, NTRK1, LCK, NTRK2, PTK2B, BDNF, NGFR, NTF3, IRS1, PIK3R1, CD44
8	13	RELN, IL10, IL1B, LDLR, VLDLR, SORL1, LRP8, LRPAP1, LRP2, LRP1, A2M, ATP7B, CLU